Table 1.
Relationship between diabetes and destruction of glycocalyx
| Sr. No | Author/year | Journal | Database | Study type | Conclusion |
|---|---|---|---|---|---|
| 1 | Wang/ 2020 | Biochimica et Biophysica Acta (BBA)—Molecular Basis of Disease | Science Direct | Experimental | Loss of podocytes → glomerular volume expansion → severe albuminuria |
| 2 | Desideri/ 2019 | Biorheology | Pubmed | Review | VEGF → albuminuria / albuminuria → eGlx damage |
| 3 | Korakas/ 2019 | Current Vascular Pharmacology | Pubmed | Review | Diabetes → oxidative stress → albuminuria → destruction of the glycocalyx layer |
| 4 | Petrica/ 2017 | Diabetology & Metabolic Syndrome | Pubmed | Cross-Sectional | Podocytes levels → proteins in urine → severity of diabetic nephropathy |
| 5 | Boels/ 2017 | The American Journal of Pathology | Science Direct/ Pubmed | Experimental | expression of heparanase enzyme → degradation and repair of glycocalyx |
| 6 | Najafi/ 2017 | Nephrology | Pubmed | Experimental | Diabetes → oxidative stress → increasing ICAM-1 & TNF-α / TNF-α → increasing glomerular permeability to albumin |
| 7 | Winther/ 2017 | Artery Research | Science Direct | Cross-Sectional | Higher PBR → Smaller glycocalyx width / Higher albuminuria → Higher PBR → impaired glycocalyx |
| 8 | Allison/ 2016 | American Diabetes Association | Pubmed | Experimental | regulation of heparanase enzyme → reduced progressive albuminuria |
An overview of the relationship between the points extracted and other articles: Diabetes causes super-structural changes in the kidney nephrons at the glomerular level through oxidative stress and causes changes in eGlx