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(A) Structural domains of AKT. AKT1, AKT2 and AKT3 share common domain structure with other members of the cAMP‐dependent, cGMP‐dependent and protein kinase C (AGC) subfamily of protein kinases: this consists of an N‐terminus pleckstrin homology (PH) domain, a large central kinase domain and a C‐terminus hydrophobic domain. (B) The PI3K-AKT-mTOR pathway. A selection of the downstream targets of AKT is shown.
