Table 1. Study eligibility criteria and definitions.

Eligibility criteria
Inclusion criteria	•   Male or female neonate, corrected age of <28 days    •   Willingness and ability of neonate’s caregiver to provide informed consent and to be available for follow-up for the planned duration of the study
Exclusion criteria	•   Receiving mechanical ventilation or continuous positive airway pressure    •   Skin abnormalities in the nasopharynx and/or oropharynx    •   Contraindication to the application of skin sensors    •   Known arrhythmia    •   Any medical or psychosocial condition or circumstance that, in the opinion of the investigators, would interfere with the conduct of the study or for which study participation might jeopardize the neonate’s health
Study definitions
Epoch	A 60-second period of time
Heartbeat	One pulsation of the heart, including one complete contraction and dilatation
Heart rate (HR)	Number of heart beats within an epoch
Breath	One cycle of inhalation and exhalation
Breath duration	Length of time from the start to the end of a single breath
Respiratory rate (RR)	Number of breaths initiated within an epoch
Pulse oximetry signal quality index (PO-SQI)	Automated indicator of signal quality from the plethysmographic recording.
CO 2-SQI	Algorithm-defined indicator of signal quality from the capnography channel
Accuracy	The closeness a measured value is from the true value
Repeatability	The closeness of the results of successive measurements of the same measure
Agreement (between measures)	The consistency between two sets of measurements
Accuracy Threshold	A pre-specified value used to determine if a set of measurements has achieved a sufficient accuracy when compared with a reference value
Precision	The closeness of measurements to each other