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. 2021 Nov 8;9:738081. doi: 10.3389/fbioe.2021.738081

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Copyright © 2021 Liu, Zhou, Chen, Lv, Huang, Peng, Wu, Chen, Tang, Guo, Wang, Zhang, Liu, Yang, Yu and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Alginate microencapsulated vHepLPC spheroids significantly improved the survival rate of mice with liver injury. (A) Alginate microcapsule coating protocol diagram. (B) Bright-field image of coated spheroids. (C) Cell viability test after microencapsulation. (D) Survival curve for acute liver injury mice with microencapsulated HepLPC spheroids (n = 10), vHepLPC spheroids (n = 11), or empty (n = 6) transplantation. (E) The microcapsule particles were enriched around the liver after transplantation. (F) Microcapsules recovered from the mouse abdominal cavity. (G) Serum levels of ALT and AST in CCL4-treated mice before and after transplantation (days one through seven) of microencapsulated spheroids. (H) Serum levels of human albumin secretion in CCL4-treated mice. (I) H&E staining 7 days after transplantation of alginate microencapsulated spheroids. The liver tissue after transplantation was significantly closer to normal tissue morphology. Data are presented as means ± SEM. **p < 0.01. Scale bars, 100 µm.