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. 2021 Nov 8;12:775447. doi: 10.3389/fimmu.2021.775447

Table 1.

Basal CD11d expression amongst leukocytes of various species.

Organism Tissue Cell Type or Sample Source Basal Expression Reference
Human Periphery CD14++CD16- monocyte + (7, 72)AB,A
CD14+CD16+ monocyte + (7, 72)AB,A
B cell + (6)A
NK cell ++ (6, 73)A,B
αβ T cell -/+ (6)A
γδ T cell + (6)A
Eosinophil + (67)A
Basophils ++ (67)A
Neutrophil + (7, 67, 73, 74)A,A,A,B
In vitro cultured Myeloid derived dendritic cell + (7)B
Myeloid derived monocyte + (7)B
6-sulfo LacNAc+ dendritic cell ++ (73)B
Spleen Splenic red pulp macrophage ++++ (5)C
Splenic red pulp granulocyte ++++ (5)C
Synovial Joints Synovial macrophage ++ (71)C
Liver Kupffer cell (5)C
Mouse Periphery Peripheral leukocyte -/+ (38, 39, 75)A,A,B
Neutrophil + (76)A
Monocyte + (76)A
Spleen Splenic red pulp macrophage ++++ (38, 77)BC,D
Peritoneum Peritoneal macrophage -/+ (38, 78)A,B
Bone Marrow Macrophage ++ (38)BC
Thymus Macrophage ++ (38)BC
Liver Kupffer cell (38)B
Lungs Lung homogenate -/+ (77)D
Rat Periphery Peripheral leukocyte -/+ (79)A
Neutrophil -/+ (79)AB
Monocyte -/+ (79)AB
Lungs Lung homogenate + (80)E
Spleen Splenic red pulp macrophage ++++ (79)AE
Canine Periphery Peripheral leukocyte -/+ (4)A
CD8+ T cell + (4)A
Spleen Splenic red pulp macrophage ++++ (4)AC
Liver Kupffer cell (4)AC

Expression is represented on a scale of – (not detected) to ++++ (highly expressed). A limitation encountered when comparing CD11d expression across studies was the variation in detection method: flow cytometry (A), immunocytochemistry (B), immunohistochemistry (C), quantitative PCR (D), and western blot (E).