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IgA1 Oglycans (A) Structure of human IgA1. The hinge region of IgA1 usually contains three to six O-linked glycan sites. (B) Variants of IgA1 O-glycan. (C) Synthesis of human IgA1 O-glycans. Upregulated α-N-acetylgalactosaminide α2,6-sialyltransferase 2 and down regulated core 1 β1,3-galactosyltransferase (and Cosmc) can lead to the increase of galactose-deficient IgA1.
