Table 3. Adjusted Absolute Risk Reduction of Any Fracture and Hip Fracture Associated With Parathyroidectomy at 1, 2, 5, and 10 Years After Treatmenta.
| Fracture type | Time point, y | Adjusted ARR, % (95% CI) |
|---|---|---|
| Any fracture | ||
| 1 | 0.67 (0.52-0.82) | |
| 2 | 1.2 (1.0-1.4) | |
| 5 | 2.8 (2.5-3.1) | |
| 10 | 5.1 (4.6-5.5) | |
| Hip fracture | ||
| 1 | 0.18 (0.11-0.26) | |
| 2 | 0.36 (0.26-0.46) | |
| 5 | 0.98 (0.81-1.2) | |
| 10 | 2.3 (2.0-2.6) | |
Abbreviations: ADI, area deprivation index; ARR, absolute risk reduction; PHPT, primary hyperparathyroidism.
a
Inverse probability weighted and adjusted for sex, age group, race and ethnicity, ADI, urban or rural inhabitance, frailty, Charlson-Deyo Comorbidity Index, operative indications for parathyroidectomy (history of osteoporosis, kidney stones, or stage 3 chronic kidney disease), endocrinologist care within 6 months of PHPT diagnosis, prior fracture, tobacco use, alcohol use disorder, and obesity.