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. 2021 Nov 29;182(1):1–9. doi: 10.1001/jamainternmed.2021.6844

Table 2. Overall Frequency of Device Complications Stratified by Indication for Use.

Outcome No. (%)
Total Midline PICC
Short-term IV antibiotic therapy
No. 6148 2046 4102
Any major complication 433 (7.0) 71 (3.5) 362 (8.8)
Primary BSI 77 (1.3) 5 (0.2) 72 (1.8)
Catheter occlusion 281 (4.6) 45 (2.2) 236 (5.8)
DVT 81 (1.3) 20 (1.0) 61 (1.5)
Pulmonary embolism 12 (0.2) 3 (0.1) 9 (0.2)
Difficult IV access
No. 6001 3694 2307
Any major complication 426 (7.1) 146 (4.0) 280 (12.1)
Primary BSI 42 (0.7) 15 (0.4) 27 (1.2)
Catheter occlusion 291 (4.8) 69 (1.9) 222 (9.6)
DVT 99 (1.6) 60 (1.6) 39 (1.7)
Pulmonary embolism 13 (0.2) 7 (0.2) 6 (0.3)

Abbreviations: BSI, bloodstream infection; DVT, deep vein thrombosis; IV, intravenous; PICC, peripherally inserted central catheter.