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. 2021 Nov 9;11:727130. doi: 10.3389/fonc.2021.727130

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Copyright © 2021 Chen, Zhang, Du, Xie, Xia, Hou, Hao and Deng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CNC extract induce cell death by promoting ferroptosis. (A) The ferrostatin-1 rescue experiment. (B) Ferroptosis-associated proteins quantification by mass spectrometry-based targeted proteomics (PRM). (C) The detection of HCT116 cellular ROS accumulation. (D) The TEM analysis of HCT116 and HCT15 cells morphology. (E, F) The detection of cellular Fe and GSH content. (F) Expression of relevant proteins at mRNA level were detected by q-PCR. (G) Expression of GPX4 and HMOX1 in HCT116 cells was measured by western blot. There were three duplicate samples in each experiment. Data are expressed as mean ± SD. Compared with control group: *p < 0.5, **p < 0.01.