TABLE 3.
Univariate and multivariate analysis for DFS
| Characteristics | Univariate analysis for DFS | Multivariate analysis for DFS | ||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| HR | 95.0% CI for HR | p | HR | 95.0% CI for HR | p | |
| Age | ||||||
| Year | 0.988 | 0.955–1.021 | 0.459 | |||
| Gender | ||||||
| Female vs. male | 0.703 | 0.304–1.626 | 0.410 | |||
| ECOG PS | ||||||
| 0+1 vs. 2 | 1.810 | 0.764–4.282 | 0.177 | 2.991 | 1.160–7.713 | 0.023 |
| HT | ||||||
| Yes vs. no | 2.255 | 0.885–5.739 | 0.088 | |||
| DM | ||||||
| Yes vs. no | 0.945 | 0.568–4.321 | 0.440 | |||
| CIHD | ||||||
| Yes vs. no | 3.506 | 0.815–15.080 | 0.092 | |||
| COPD | ||||||
| Yes vs. no | 0.760 | 0.102–5.602 | 0.789 | |||
| Smoking | ||||||
| Yes vs. no | 0.989 | 0.389–2.514 | 0.982 | |||
| Dysphagia | ||||||
| Yes vs. no | 1.961 | 0.902–4.649 | 0.466 | |||
| Abdominal pain | ||||||
| Yes vs. no | 1.727 | 0.584–5.104 | 0.323 | |||
| Weight loss | ||||||
| Yes vs. no | 1.434 | 0.584–3.522 | 0.431 | |||
| Obstruction | ||||||
| Yes vs. no | 2.391 | 0.877–6.517 | 0.088 | 3.252 | 1.134–9.323 | 0.028 |
| Localization | ||||||
| Middle 2/3 vs. lower 1/3 | 0.526 | 0.452–0.927 | 0.045 | 0.623 | 0.427–0.859 | 0.042 |
| Grade | ||||||
| 3 vs. 1+2 | 1.617 | 0.542–4.819 | 0.388 | |||
| Neoadjuvant | ||||||
| Yes vs. no | 0.506 | 0.187–0.951 | 0.017 | 0.585 | 0.207–0.952 | 0.011 |
| Stage | ||||||
| III vs. I+II | 2.121 | 1.916–4.910 | 0.019 | 2.541 | 1.258–5.968 | 0.001 |
| CEA | 0.875 | 0.573–1.334 | 0.534 | |||
| CA19-9 | 0.962 | 0.898–1.301 | 0.272 | |||
| TNC | 1.000 | 0.999–1.002 | 0.155 | |||
| TLC | 1.000 | 0.999–1.000 | 0.516 | |||
| TMC | 0.999 | 0.997 | 0.481 | |||
| Hb | 0.892 | 0.726–1.094 | 0.273 | |||
| TPC | 1.000 | 0.999–1.001 | 0.836 | |||
| NLR | ||||||
| ≥2.8 vs. <2.8 | 2.983 | 1.260–7.055 | 0.013 | 5.445 | 2.081–4.547 | 0.001 |
| PLR | 1.002 | 0.997–1.005 | 0.383 | |||
DFS: Disease-free survival; HR: Hazard ratio; CI: Confidence interval; ECOG PS: Eastern Cooperative Oncology Group Performance Score; HT: Hypertension; DM: Diabetes mellitus; CIHD: Chronic ischemic heart disease; COPD: Chronic obstructive pulmonary disease; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; TNC: Total neutrophil count; TLC: Total lymphocyte count; TMC: Total monocyte count; Hb: Hemoglobin; TPC: Total platelet count; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; vs.: Versus.