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. 2021 Nov 9;12:764462. doi: 10.3389/fimmu.2021.764462

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Copyright © 2021 Symonds, Marcu, Cook, Metheringham, Durrant and Brentville

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Eluted citrullinated peptides show CD4 IL-10 regulatory immune responses. HLA-DP4 (A) transgenic mice were immunised with 25ug of individual citrullinated peptides on days 1, 8 and 15 and immune responses specific to the citrullinated peptides were monitored on day 21 by IL-10 Elispot assay and compared to control. Immune responses in mice immunised with 25ug citCp450 were analysed in the presence of CD4 or CD8 blocking antibody (B). IL-10 responses to citCp450 were compared in HHDII/DP4 and HHDI/DR1 mice (C). Analysis of IL-10 responses from vaccination with the 7 peptide combination vaccine (D). Results are shown from a representative example (C) or at least two independent experiments in which n=3.