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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: J Mol Cell Cardiol. 2021 Jun 1;158:115–127. doi: 10.1016/j.yjmcc.2021.05.016

Figure 4. GPI protein levels are decreased in parallel with increased mTOR phosphorylation during acute exercise after six days of voluntary exercise training.

Figure 4.

(A) Representative home cage circadian activity of sedentary and voluntarily exercising C57BL6/J mice, as measured by infrared motion detector (left columns) and wheel runner reed switches (right columns). (B) Heart weight to body weight ratio does not differ between groups after 6 days of voluntary exercise (n=6 mice per group). (C) mTOR phosphorylation at Ser2448 is increased in voluntarily exercised C57BL6/J mice (n=6 mice per group). (D) TSC2 phosphorylation at Ser1387 is decreased in voluntarily exercised C57BL6/J mice (n=6 mice per group). (E) GPI protein levels are decreased in the hearts of voluntarily exercised C57BL6/J mice (n=6 mice per group). (F) GPI activity is increased in the hearts of voluntarily exercised C57BL6/J mice (n=6 mice per group) (G) G6P levels in the hearts of voluntarily exercised mice are not significantly increased (n=6 mice per group). (H) AMPK phosphorylation at Thr172 is unchanged in voluntarily exercised C57BL6/J mice (n=6 mice per group). Statistical significance was calculated using unpaired two-tailed Student’s t test; *p<0.05, ** p<0.01.