. Author manuscript; available in PMC: 2022 Sep 1.

Published in final edited form as: J Mol Cell Cardiol. 2021 Jun 1;158:115–127. doi: 10.1016/j.yjmcc.2021.05.016

Table 2.

Echocardiographic parameters in mTORC1^iSA mice fed either rapamycin or vehicle diet at 28 weeks.

Parameter	Vehicle (n=6)	Rapamycin (n=6)

LVAWd (mm)	1.18 ± 0.06	0.87 ± 0.07^**
LVAWs (mm)	1.70 ± 0.07	1.28 ± 0.10^**
LVIDd (mm)	3.42 ± 0.19	3.99 ± 0.16^*
LVIDs (mm)	2.06 ± 0.19	2.86 ± 0.23^*
LVPWd (mm)	1.04 ± 0.06	0.99 ± 0.10
LVPWs (mm)	1.50 ± 0.09	1.39 ± 0.13
EF (%)	73.76 ± 2.93	57.39 ± 4.65^*
FS (%)	42.13 ± 2.38	30.17 ± 3.09^*
Heart rate (bpm)	382.3 ± 13.49	413.7 ± 9.82
Relative Wall Thickness	0.66 ± 0.06	0.47 ± 0.04^*
E/A^a	1.90 ± 0.08	1.45 ± 0.25
E/e’	33.97 ± 1.71	38.04 ± 4.31
IVRT/RR	0.14 ± 0.02	0.14 ± 0.01

LVAWd: Left Ventricular Anterior Wall in diastole. LVAWs: Left Ventricular Anterior Wall in systole. LVIDd: Left Ventricular Internal Diameter in diastole. LVIDs: Left Ventricular Internal Diameter in systole. LVPWd: Left Ventricular Posterior Wall in diastole. LVPWs: Left Ventricular Posterior Wall in systole. EF: Ejection Fraction. FS: Fractional Shortening.

Statistical significance was calculated using unpaired two-tailed Student’s t test, with the exception of, calculated with unpaired two-tailed Student’s t test with Welch’s correction

p<0.05

^**

p<0.01.