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. 2021 Nov 22;25(1):24. doi: 10.3892/mmr.2021.12540

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Copyright: © Gao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Sch A regulates ANP, BNP, B-MHC, pAKT/AKT and p-CREB/CREB via miR-155. (A) mRNA expression levels of ANP, BNP and B-MHC were measured using reverse transcription-quantitative PCR. GAPDH was used as a control. (B) The protein expression of AKT, p-AKT, CREB and p-CREB was semi-quantified by western blotting; GAPDH was used as a control. (C) The ratio of p-AKT to AKT. (D) The ratio of p-CREB to CREB. ***P<0.001 vs. Blank; ^▲▲▲P<0.001 vs. ISO + IC; ^###P<0.001 vs. ISO; ^{^^^}P<0.001 vs. ISO + Sch A + MC. Sch A, Schisandrin A; miR, microRNA; ANP, atrial natriuretic peptide; BNP, B-type natriuretic peptide; B-MHC, B-myosin heavy chain; p-, phosphorylated; CREB, cyclic AMP response-element binding protein; M, miR-155 mimic; MC, miR-155 mimic control; I, miR-155 inhibitor; IC, miR-155 inhibitor control; ISO, isoproterenol.