Table 1:
Parameter | Estimation Method and Species | Value | Reference |
---|---|---|---|
Urine excretion rate | |||
0.00125 L/kg-hour | Wittassek, 2011 32 | ||
0.001-0.002 L/kg-hour | Hazinski, 2012 31 | ||
TDCIPP urinary excretion fraction | |||
In vivo; rat | 63% | Lynn, 1981 36 | |
TDCIPP metabolism | |||
In vitro; human liver S9 fraction | 68% | Van den Eede, 2013 33 | |
In vitro; human liver microsome (HLM) | 46% | Van den Eede, 2013 33 | |
In vitro; rat liver homogenate | 43% | Sasaki, 1984 35 |