Fig. 1.
IHT for 14 days or 28 days alleviates memory impairment in APP/PS1 mice. a Schematic representation of the experimental design. 6-month-old APP/PS1 mice were exposed to a hypoxic environment (14.3% O2, 4 h/day) for 14 days or 28 days and then behavioral tests were performed. Mice with IHT had a shorter latency to find the platform (b), spent a significantly shorter time in first entry to the platform (c), as well as had significantly more crossing platform times in the probe trial at different time points (d), longer time (e) and longer distance (f) in goal quadrant compared to the control mice. The IHT did not significantly change the mean velocity (g). Tra, Opp, AdjL and AdjR are the number of platform crossings in the training, opposite, adjacent left, and adjacent right quadrants, respectively. Control mice (n = 11), mice with IHT 14 days (n = 11), mice with IHT 28 days (n = 10). *p<0.05; **p < 0.01; ns, not significant