Fig. 3.

IHT reduces neuropathological changes in APP/PS1 mice. a–d Representative immunohistochemical images stained with antibodies against Aβ (a, b), Neurofilament-L (c), and IBA1(d). The Aβ plaque numbers were significantly reduced in the hippocampus (g), but not in the cortex (e), while the area of Aβ plaques was significantly decreased in both cortex (f) and hippocampus (h) in mice with IHT 14 days compared to the control ones. The area of neurofilament accumulation (i) and IBA1-positive cells aggregation (j) were significantly reduced in mice with IHT 14 days compared to the control ones. n = 6; *p<0.05; **p < 0.01; ns, not significant