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Working model of IHT alleviates memory impairment in 6-month-old APP/PS1 mice, reduces amyloid accumulation and inflammation in the brain. IHT for 14 days or 28 days, 14 days with interval of 14 days alleviates memory impairment in APP/PS1 mice. IHT reduced the pro-inflammatory cytokines IL-1β, IL-6 levels, and increased ADAM10 and decreased BACE1 of APP processing thus decreasing Aβ production
