Fig. 7.

CircCRIM1 binds with miR-383-5p to promote ovarian cancer progression. Circular RNA Interactome predicted miR-383-5p might bind with circCRIM1 and the dual luciferase reporter assay was performed to verify it (a and b). MicroRNA mimics over-expression ability was verified (c). CircCRIM1 enhancement or knockdown has positively effect on ZEB2 (d). MiR-383-5p mimics treatment after circCRIM1 over-expression reversed the promotion effect of circCRIM1 on viability, migration, invasion ability and ZEB2 expression, similarly increased apoptic rate (e, f, g, h and i). Three separate experiments were conducted; data are shown as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001