Table 1.
Clinical characteristics and laboratory parameters of older patients with or without CKD
| Control subjects | CKD patients | P value | |
|---|---|---|---|
| Number of cases | 76 | 143 | |
| Age, years | 80.32 ± 4.34 | 82.70 ± 4.89 | < 0.001* |
| Gender (M/F) | 60/16 | 115/28 | < 0.001* |
| Hypertension | 60.53% | 86.01% | < 0.001* |
| Systolic blood pressure, mmHg | 134.37 ± 16.78 | 143.66 ± 16.62 | < 0.001* |
| Diastolic blood pressure, mmHg | 71.17 ± 9.09 | 74.66 ± 10.22 | 0.005* |
| Diabetes | 23.68% | 42.66% | 0.005* |
| SCr (μmol/L) | 77.64 ± 11.47 | 145.55 ± 50.42 | < 0.001* |
| eGFR CKD − EPI (ml/min/1.73 m2) | 78.32 ± 10.65 | 40.98 ± 13.49 | < 0.001* |
| Albumin (g/L) | 35.00 ± 33.72 | 33.72 ± 4.97 | 0.075 |
| protein/creatinine ratio (mg/g Cr) | 115.17 ± 98.40 | 776.87 ± 1587.69 | < 0.001* |
| Cholesterol (mmol/L) | 4.19 ± 0.90 | 4.43 ± 1.29 | 0.401 |
| Triglyceride (mmol/L) | 1.12 ± 0.60 | 1.36 ± 0.89 | 0.040* |
| IMT (cm) | 0.94 ± 0.16 | 1.01 ± 0.17 | 0.006* |
| WBC (109 /L) | 6.17 ± 1.95 | 6.43 ± 1.92 | 0.247 |
| Neutrophil (109 /L) | 3.75 ± 1.51 | 4.20 ± 1.59 | 0.027* |
| T lymphocytes (109 /L) | 1.09 ± 0.44 | 0.33 ± 0.21 | 0.175 |
| Total CD19(+) B lymphocytes (109 /L) | 0.22 ± 0.36 | 0.15 ± 0.11 | 0.059 |
| CD19(+)CD5(+) B lymphocytes (109 /L) | 0.10 ± 0.33 | 0.05 ± 0.07 | 0.040* |
| CD19(+)CD5(−) B lymphocytes (109 /L) | 0.12 ± 0.09 | 0.10 ± 0.06 | 0.088 |
| Number of deaths | 9 | 46 | 0.001* |
| Follow up time | 50.37 ± 31.59 | 38.46 ± 29.56 | 0.009* |
eGFR Estimated glomerular filtration rate, SCr Serum creatinine, IMT Intima–media thickness, WBC White blood cell