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. 2021 Nov 30;29(6):8109–8125. doi: 10.1007/s11356-021-17824-5

Fig. 7.

Fig. 7

A Balancing of RAAS system by ACE1/ACE2 enzyme by balancing the ratio of angiotensin-I and angiotensin-II concentration. B Imbalance of RAAS system caused by SARS-CoV-2 by binding to ACE2 enzyme, hence inhibiting the conversion of angiotensin-II to angiotensin-I thereby promoting pro-inflammatory action