Table 3.
Antiviral profiles of 11 compounds against rCedV-Luc infection in HEK 293T and Vero E6 cell lines
| Comp. ID | IC50 (95% CI) (μM) | CC50 (95% CI) (μM) | Selectivity index (SI) | |||
|---|---|---|---|---|---|---|
| HEK 293T | Vero E6 | HEK 293T | Vero E6 | HEK 293T | Vero E6 | |
| A1 | 0.37 (0.33 to 0.41) | 2.37 (1.69 to 3.31) | >100 | >100 | >270 | >42.0 |
| A2 | 0.29 (0.25 to 0.32) | 0.73 (0.47 to 1.15) | >100 | >100 | >344 | >137 |
| A3 | 0.29 (0.26 to 0.31) | 1.29 (0.85 to 1.95) | >100 | >100 | >344 | >78.0 |
| B1 | 0.58 (0.40 to 0.85) | 0.35 (0.16 to 0.77) | >100 | >100 | >172 | >286 |
| B2 | 0.70 (0.58 to 0.86) | 1.58 (0.96 to 2.58) | >100 | >100 | >142 | >63.0 |
| C1 | 3.06 (2.72 to 3.45) | 7.82 (4.28 to 14.3) | >100 | >100 | >33.0 | >12.8 |
| F1 | 10.0 (9.29 to 10.7) | 11.8 (8.70 to 16.1) | 85.8 (59.1 to 124) | >100 | 8.58 | >8.50 |
| Z | 0.13 (0.07 to 0.22) | 0.41 (0.18 to 0.96) | >100 | >100 | >769 | >244 |
Note: All IC50 and CC50 values are estimated by nonlinear fit model from three independent experiments and shown as estimated values with 95% confidence interval (95% CI).