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. 2021 Nov 9;9:760800. doi: 10.3389/fcell.2021.760800

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Copyright © 2021 Ye, Liu, Liu and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Validation using collected samples and prediction of therapy efficacy. (A–D) The efficacies of radiation therapy, chemotherapy, targeted therapy, and immunotherapy in the TCGA cohort. (E–H) The efficacies of radiation therapy, chemotherapy, targeted therapy, and immunotherapy in the CGGA cohort. (I–K) The relationship between functional states and HMOX1 expression based on single-cell sequencing. (L) Prediction of response to immunotherapy using TIDE algorithm. **p < 0.01, ***p < 0.001. TIDE, Tumor Immune Dysfunction and Exclusion.