TABLE 2.
The correlations between HMOX1 and M2 macrophage phenotypes in LGG based on cell markers.
| M2 Macrophage phenotype | Functions | Inducers | Markers and surface molecules | Gene name | Spearman’s rho | p-value |
| M2a macrophage | Type II inflammation; | IL-4 | CD163 | CD163 | 0.584 | 1.49E-48 |
| Allergy; | IL-13 | CD200R1 | CD200R1 | 0.279 | 1.15E-10 | |
| Killing and encapsulation of parasites; | CD301 | CLEC10A | 0.513 | 4.70E-36 | ||
| Anti-inflammation; | CXCR1 | CXCR1 | 0.161 | 2.37E-04 | ||
| Wound healing. | CXCR2 | CXCR2 | 0.526 | 4.28E-38 | ||
| CD209 | CD209 | 0.267 | 6.65E-10 | |||
| Dectin-1 | CLEC7A | 0.649 a | 4.28E-63 | |||
| FCERA | FCER1A | 0.441 | 6.18E-26 | |||
| IL-1R2 | IL1R2 | 0.280 | 9.59E-11 | |||
| IL-4R | IL4R | 0.589 | 2.03E-49 | |||
| CD206 | MRC1 | 0.090 | 0.0409 | |||
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| M2b macrophage | Th2 activation; | Lipopolysaccharides | CD86 | CD86 | 0.752 a | 5.48E-59 |
| Immunoregulation; | Immune complexes | HLA-DR | HLA-DRA | 0.705 a | 1.30E-78 | |
| Promoting infection; | IL1R/TLR ligands | HLA-DP | HLA-DPA1 | 0.672 a | 5.00E-69 | |
| Tumor progression. | HLA-DQ | HLA-DQA1 | 0.621 a | 2.70E-56 | ||
| IL-4R | IL4R | 0.589 | 2.03E-49 | |||
| CD206 | MRC1 | 0.090 | 0.0409 | |||
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| M2c macrophage | Immunosuppression; | IL-10 | CCR2 | CCR2 | 0.506 | 6.69E-35 |
| Tissue remodeling; | TGF-β | CD150 | SLAMF1 | 0.427 | 2.86E-24 | |
| Phagocytosis. | Glucocorticoid | CD163 | CD163 | 0.584 | 1.49E-48 | |
| IL-4R | IL4R | 0.589 | 2.03E-49 | |||
| CD206 | MRC1 | 0.090 | 0.0409 | |||
| SR-AI | MSR1 | 0.758 a | 1.72E-97 | |||
| TLR1 | TLR1 | 0.685 a | 8.93E-73 | |||
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| M2d macrophage | Tumor progression; | TLR+A2R ligands | iNOS | NOS2 | –0.232 | 9.24E-08 |
| Angiogenesis. | TNF-α (low) | TNF | 0.310 | 5.67E-13 | ||
| IL-12 (low) | IL12A | 0.089 | 0.0440 | |||
| VEGF | VEGFA | 0.095 | 0.0305 | |||
aRho greater than 0.6 was bold.
CXCR1, C-X-C chemokine receptor type 1; CXCR2, C-X-C chemokine receptor type 2; CLEC7A, C-type lectin domain family 7, member A; FCER1A, Fc fragment of IgE; MRC1, Mannose receptor, C type 1; CCR2, Chemokine (C-C motif) receptor 2; SLAMF1, Signaling lymphocytic activation molecule family member 1; MSR1, Macrophage scavenger receptor 1; TLR1, Toll-like receptor 1; NOS2, Nitric oxide synthase 2, inducible; VEGFA, Vascular endothelial growth factor A.