Table 1:

Binary Outcomes used for Construct Validity Steps in the Development and Validation Cohorts

Outcome	Details of change from baseline to 24-month visit
Radiographic
Kellgren-Lawrence Grade Progression	Any change in Kellgren-Lawrence grade
Lateral JSN Progression	Any change in lateral JSN
Medial JSN Progression	Any change in medial JSN
JSN Progression	Any change in medial or lateral JSN
Medial JSW progression	Change ≥ median change in the development dataset
Quality of Life
KQOL 1 improvement	KQOL item 1 improves from 2 worst responses to 3 best responses (how often aware of problems with knee(s))
KQOL 1 worsens	KQOL item 1 worsens from 3 best responses to 2 worst responses (how often aware of problems with knee(s))
KQOL 2 improvement	KQOL item 2 improves from 2 worst responses to 3 best responses (modified lifestyle to avoid potentially damaging activities to knee(s))
KQOL 2 worsens	KQOL item 2 worsens from 3 best responses to 2 worst responses (modified lifestyle to avoid potentially damaging activities to knee(s))
KQOL 3 improvement	KQOL item 3 improves from 2 worst responses to 3 best responses (how much troubled with lack of confidence in knee(s))
KQOL 3 worsens	KQOL item 3 worsens from 3 best responses to 2 worst responses (how much troubled with lack of confidence in knee(s))
KQOL 4 improvement	KQOL item 4 improves from 2 worst responses to 3 best responses (in general, how much difficulty have with knee(s))
KQOL 4 worsens	KQOL item 4 worsens from 3 best responses to 2 worst responses (in general, how much difficulty have with knee(s))
Pain
WOMAC pain progression	Pain increased by at least 2 points on 0–20 scale
WOMAC pain progression	Pain increased by at least 3 points on 0–20 scale
WOMAC pain improvement	Pain decreased by at least 2 points on 0–20 scale
WOMAC pain improvement	Pain decreased by at least 3 points on 0–20 scale

JSN = joint space narrowing, KQOL = KOOS Quality of Life.