Table 4:

Odds ratios and Area under the ROC curve for Composite Scores in the Validation Cohort

	Unadjusted		Adjusted*
Knee Measure	Odds Ratio (95% CI)	AUC	Odds ratio (95% CI)	AUC
Kellgren-Lawrence Grade Progression
Unweighted total score	1.29 (0.94, 1.77)	0.60	1.38 (0.97, 1.96)	0.71
Cumulative cartilage damage	1.54 (1.12, 2.11)	0.64	1.84 (1.27, 2.69)	0.72
BML+effusion-synovitis	1.17 (0.85, 1.61)	0.59	1.21 (0.86, 1.70)	0.70
Medial Joint Space Width Progression
Unweighted total score	1.20 (0.90, 1.61)	0.56	1.21 (0.89, 1.64)	0.63
Cumulative cartilage damage	1.93 (1.38, 2.72)	0.67	2.11 (1.44, 3.07)	0.70
BML+effusion-synovitis	1.05 (0.79, 1.39)	0.52	1.05 (0.78, 1.41)	0.63
WOMAC Pain Progression
Unweighted total score	1.72 (1.18, 2.52)	0.63	1.97 (1.26, 3.08)	0.76
Cumulative cartilage damage	1.28 (0.89, 1.84)	0.55	1.31 (0.86, 1.98)	0.72
BML+effusion-synovitis	1.69 (1.15, 2.48)	0.65	1.92 (1.23, 3.01)	0.76

BML = bone marrow lesion; AUC = area under the ROC curve; 95% CI = 95% confidence intervals.

^*Adjusted for age, sex, BMI, race, WOMAC pain, KL, JSW and pain med use.