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. 2021 Nov 10;11:734750. doi: 10.3389/fcimb.2021.734750

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Copyright © 2021 Wang, He, Yin, Wu and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects and changes of RAS/MAPK/ERK and PI3K/Akt signaling pathways in LO2 cells after co-cultured with recombinant CsGRN protein and EGFR inhibitor. (A) The histogram of PI and the percentage of cell cycle phase. (B) The representative images from colony formation assay and histogram of cloning efficiency. (C) The migration and invasion of LO2 cells were explored by wound healing scratch assay and Transwell assay. (D) The protein expression of RAS/MAPK/ERK and PI3K/Akt signaling pathways in LO2 cells after treated with recombinant CsGRN protein and inhibitors. Quantification of protein was measured by Image J and showed under each band. ^* P < 0.05 versus control group, ^** P < 0.01 versus control group, ^*** P < 0.001 versus control group, ^**** P < 0.0001 versus control group.