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. 2021 Nov 10;11:734853. doi: 10.3389/fonc.2021.734853

Figure 4.

Figure 4

DSF regulates PD-L1 expression through IRF7. (A) The MDA-MB-231 cell and BT-549 cell transfected with siRNA-IRF7 were treated with DSF for 48 h, and PD-L1 expression was measured by flow cytometry analysis. Right panel, quantification of relative MFI. (B) The mRNA expression level of IRF7 and PD-L1 in the MDA-MB-231 cell transfected with siRNA-IRF7 or siRNA-NC after the treatment of indicated concentration of DSF for 48 h. (C) The protein level of IRF7 and PD-L1 in MDA-MB-231 cell and BT-549 cell treated with siRNA-IRF7 or treated with siRNA-IRF7 or siRNA-NC were measured by western blotting after treatment with indicated doses of DSF for 48 h. **p < 0.01, ***p < 0.001. ns, no statistic significance.