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. 2021 Nov 10;11:734853. doi: 10.3389/fonc.2021.734853

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Copyright © 2021 Zheng, Liu, Mi, Wen, Wu and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The modulation of tumor immune microenvironment in the combination of DSF and anti-PD-1 therapy. (A) Heat map shows gene expression profiles of a selected list of the immune microenvironment showing fold changes in the groups of control, DSF, anti-PD-1 antibody, combination. (B) The MCP counter algorithm was utilized to analyze the degree of infiltration of immune cells with mRNA expression in the groups of control, DSF, pd-1, combination. (C) The Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analyses of mRNAs in the groups of control vs DSF. (D) KEGG functional enrichment analysis of the anti-PD-1 blocking antibody groups and the combination of DSF and the anti-PD-1 blocking antibody groups based on GSEA.