Table 1.
Characteristics of SNPs for habitual coffee consumption from the GWAS meta-analysis.
GWAS | chr | Pos | SNP | Closest gene | EA | OA | EAF | Effect | SE | P value | N |
---|---|---|---|---|---|---|---|---|---|---|---|
Primary (% change) | 1 | 177873210 | rs574367 | SEC16B | T | G | 0.21 | 1.05 | 0.18 | 8.E-09 | 376372 |
Primary | 2 | 631606 | rs10865548 | TMEM18 | G | A | 0.83 | 1.54 | 0.19 | 4.46E-15 | 376372 |
Primary | 2 | 27730940 | rs1260326 | GCKR | C | T | 0.61 | 1.36 | 0.15 | 2.62E-19 | 376372 |
Primary | 7 | 17284577 | rs4410790 | AHR | C | T | 0.63 | 3.94 | 0.15 | 5.59E-141 | 376372 |
Primary | 7 | 73037956 | rs34060476 | MLXIPL | G | A | 0.13 | 1.89 | 0.22 | 5.06E-18 | 376372 |
Primary | 7 | 75615006 | rs1057868 | POR | T | C | 0.29 | 1.97 | 0.16 | 5.26E-33 | 376372 |
Primary | 11 | 56272114 | rs597045 | OR8U8 | A | T | 0.69 | 1.07 | 0.16 | 6.62E-11 | 376372 |
Primary | 14 | 33075243 | rs1956218 | AKAP6 | G | A | 0.56 | 0.82 | 0.15 | 3.62E-08 | 376372 |
Primary | 15 | 75027880 | rs2472297 | CYP1A1/2 | T | C | 0.27 | 4.54 | 0.17 | 5.19E-155 | 376372 |
Primary | 18 | 57808978 | rs66723169 | MC4R | A | C | 0.23 | 1.47 | 0.18 | 9.88E-17 | 376372 |
Primary | 22 | 24747031 | rs2330783 | SPECC1L-ADORA2A | G | T | 0.99 | 4.53 | 0.63 | 1.57E-12 | 376372 |
Secondary (Cups/day) | 2 | 27584444 | rs1260326 | GCKR | T | C | 0.41 | -0.04 | 0.01 | 1.06E-07 | 91462 |
Secondary | 4 | 89258106 | rs1481012 | ABCG2 | A | G | 0.89 | 0.06 | 0.01 | 1.13E-06 | 91462 |
Secondary | 7 | 17251102 | rs4410790 | AHR | T | C | 0.37 | -0.14 | 0.01 | 1.48E-57 | 91462 |
Secondary | 7 | 72673793 | rs7800944 | MLXIPL | T | C | 0.72 | -0.05 | 0.01 | 7.82E-09 | 91462 |
Secondary | 7 | 75454041 | rs17685 | POR | A | G | 0.29 | 0.07 | 0.01 | 9.06E-14 | 91462 |
Secondary | 11 | 27636492 | rs6265 | BDNF | T | C | 0.19 | -0.05 | 0.01 | 3.40E-07 | 91462 |
Secondary | 15 | 72814933 | rs2472297 | CYP1A2 | T | C | 0.24 | 0.15 | 0.01 | 6.45E-47 | 91462 |
Secondary | 17 | 25373221 | rs9902453 | EFCAB5 | A | G | 0.54 | -0.04 | 0.01 | 2.26E-06 | 91462 |
Chr, chromosome; Pos, position for SNP; Closet gene, the nearest gene to coffee consumption associated SNP; Effect, the per-allele effect on coffee consumption; P value, the value for the genetic association; GWAS, genome-wide association study; SNP, single-nucleotide polymorphism; EA, effect allele; OA, other allele; EAF, effect allele frequency; SE, standard error.