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. 2021 Nov 10;12:768529. doi: 10.3389/fendo.2021.768529

Table 1.

Characteristics of SNPs for habitual coffee consumption from the GWAS meta-analysis.

GWAS chr Pos SNP Closest gene EA OA EAF Effect SE P value N
Primary (% change) 1 177873210 rs574367 SEC16B T G 0.21 1.05 0.18 8.E-09 376372
Primary 2 631606 rs10865548 TMEM18 G A 0.83 1.54 0.19 4.46E-15 376372
Primary 2 27730940 rs1260326 GCKR C T 0.61 1.36 0.15 2.62E-19 376372
Primary 7 17284577 rs4410790 AHR C T 0.63 3.94 0.15 5.59E-141 376372
Primary 7 73037956 rs34060476 MLXIPL G A 0.13 1.89 0.22 5.06E-18 376372
Primary 7 75615006 rs1057868 POR T C 0.29 1.97 0.16 5.26E-33 376372
Primary 11 56272114 rs597045 OR8U8 A T 0.69 1.07 0.16 6.62E-11 376372
Primary 14 33075243 rs1956218 AKAP6 G A 0.56 0.82 0.15 3.62E-08 376372
Primary 15 75027880 rs2472297 CYP1A1/2 T C 0.27 4.54 0.17 5.19E-155 376372
Primary 18 57808978 rs66723169 MC4R A C 0.23 1.47 0.18 9.88E-17 376372
Primary 22 24747031 rs2330783 SPECC1L-ADORA2A G T 0.99 4.53 0.63 1.57E-12 376372
Secondary (Cups/day) 2 27584444 rs1260326 GCKR T C 0.41 -0.04 0.01 1.06E-07 91462
Secondary 4 89258106 rs1481012 ABCG2 A G 0.89 0.06 0.01 1.13E-06 91462
Secondary 7 17251102 rs4410790 AHR T C 0.37 -0.14 0.01 1.48E-57 91462
Secondary 7 72673793 rs7800944 MLXIPL T C 0.72 -0.05 0.01 7.82E-09 91462
Secondary 7 75454041 rs17685 POR A G 0.29 0.07 0.01 9.06E-14 91462
Secondary 11 27636492 rs6265 BDNF T C 0.19 -0.05 0.01 3.40E-07 91462
Secondary 15 72814933 rs2472297 CYP1A2 T C 0.24 0.15 0.01 6.45E-47 91462
Secondary 17 25373221 rs9902453 EFCAB5 A G 0.54 -0.04 0.01 2.26E-06 91462

Chr, chromosome; Pos, position for SNP; Closet gene, the nearest gene to coffee consumption associated SNP; Effect, the per-allele effect on coffee consumption; P value, the value for the genetic association; GWAS, genome-wide association study; SNP, single-nucleotide polymorphism; EA, effect allele; OA, other allele; EAF, effect allele frequency; SE, standard error.