Table 1.

Characteristics of SNPs for habitual coffee consumption from the GWAS meta-analysis.

GWAS	chr	Pos	SNP	Closest gene	EA	OA	EAF	Effect	SE	P value	N
Primary (% change)	1	177873210	rs574367	SEC16B	T	G	0.21	1.05	0.18	8.E-09	376372
Primary	2	631606	rs10865548	TMEM18	G	A	0.83	1.54	0.19	4.46E-15	376372
Primary	2	27730940	rs1260326	GCKR	C	T	0.61	1.36	0.15	2.62E-19	376372
Primary	7	17284577	rs4410790	AHR	C	T	0.63	3.94	0.15	5.59E-141	376372
Primary	7	73037956	rs34060476	MLXIPL	G	A	0.13	1.89	0.22	5.06E-18	376372
Primary	7	75615006	rs1057868	POR	T	C	0.29	1.97	0.16	5.26E-33	376372
Primary	11	56272114	rs597045	OR8U8	A	T	0.69	1.07	0.16	6.62E-11	376372
Primary	14	33075243	rs1956218	AKAP6	G	A	0.56	0.82	0.15	3.62E-08	376372
Primary	15	75027880	rs2472297	CYP1A1/2	T	C	0.27	4.54	0.17	5.19E-155	376372
Primary	18	57808978	rs66723169	MC4R	A	C	0.23	1.47	0.18	9.88E-17	376372
Primary	22	24747031	rs2330783	SPECC1L-ADORA2A	G	T	0.99	4.53	0.63	1.57E-12	376372
Secondary (Cups/day)	2	27584444	rs1260326	GCKR	T	C	0.41	-0.04	0.01	1.06E-07	91462
Secondary	4	89258106	rs1481012	ABCG2	A	G	0.89	0.06	0.01	1.13E-06	91462
Secondary	7	17251102	rs4410790	AHR	T	C	0.37	-0.14	0.01	1.48E-57	91462
Secondary	7	72673793	rs7800944	MLXIPL	T	C	0.72	-0.05	0.01	7.82E-09	91462
Secondary	7	75454041	rs17685	POR	A	G	0.29	0.07	0.01	9.06E-14	91462
Secondary	11	27636492	rs6265	BDNF	T	C	0.19	-0.05	0.01	3.40E-07	91462
Secondary	15	72814933	rs2472297	CYP1A2	T	C	0.24	0.15	0.01	6.45E-47	91462
Secondary	17	25373221	rs9902453	EFCAB5	A	G	0.54	-0.04	0.01	2.26E-06	91462

Chr, chromosome; Pos, position for SNP; Closet gene, the nearest gene to coffee consumption associated SNP; Effect, the per-allele effect on coffee consumption; P value, the value for the genetic association; GWAS, genome-wide association study; SNP, single-nucleotide polymorphism; EA, effect allele; OA, other allele; EAF, effect allele frequency; SE, standard error.