Table 3.
Brain regions and networks associated with breast cancer related fatigue.
| Author, year | Neuroimaging state | Regions of interest/network | Region/network associated with CRF? | xyz coordinatesa |
|---|---|---|---|---|
| TASK-RELATED ACTIVATIONS | ||||
| McDonald et al. (2012) | Verbal working memory n-back task | Increased activation of frontoparietal regions but no region associated with CRF | No | Not reported |
| López Zunini et al. (2013) | Verbal recall memory task |
Increased activation
Right medial frontal gyrus Left hippocampus Reduced activation Right anterior cingulate |
Yes | 10 36 46 −32 −28 −8 4 10 26 |
| Askren et al. (2014) | Verbal working memory task |
Reduced neural efficiency
Frontoparietal executive network |
Yes | Marker of neural efficiency associated with CRF |
| Menning et al. (2015) | Planning task Paired associates verbal memory task |
Increased activation
Dorsomedial pre-frontal cortex No changes |
Yes | 36 16 52 32 26 50 |
| Churchill et al. (2015) | Verbal working memory task | Inferior and superior frontal lobe Dorsolateral pre-frontal cortex Parietal region |
Yes | H factor (marker of neuronal processes) associated with CRF |
| Menning et al. (2017) | Planning task Paired associates verbal memory task |
Increased activation
Right inferior parietal cortex No changes |
Yes | 36 −40 38 30 −42 38 34 −40 50 |
| CONNECTIVITY CHANGES | ||||
| Hampson et al. (2015) | Resting state |
Fatigue
>
non-fatigue
Inferior parietal lobule to superior frontal gyrus (physical fatigue) DMN to superior frontal gyrus (mental fatigue) Medial frontal gyrus to inferior parietal lobule (mental fatigue) Posterior cingulate to cerebellum Non-fatigue > fatigue Right precuneus to the superior colliculus/periaqueductal gray Inferior parietal lobule to right parahippocampus Left inferior parietal lobule to subgenual anterior cingulate Left posterior cingulate to middle temporal gyrus Left precuneus to primary somatosensory |
Yes | 34 28 48 −35 31 37 44 −68 34 52 −72 −40 2 −34 −4 26 −36 −12 −4 16 −26 40 −54 4 −48 −18 42 |
| Harris et al. (2017) | Resting state | Insula to dorsolateral pre-frontal cortex DMN to left pulvinar thalamus DMN to right pulvinar thalamus DMN to superior colliculus/periaqueductal gray |
Yes | −37 45 21 −19 −31 15 13 −33 13 −3 −31 −3 |
| Van der Gucht et al. (2020) | Resting state | Between dorsal and salience attention networks | Yes | Not reported |
a
xyz Coordinates of Peak Voxel of Region Associated With CRF Using MNI (Montreal Neurological Institute) System. DMN, Default mode network.