Table 4.
Clinical results of subgroup analyses on comparison between intravenous thrombolysis and control group.
| No. of participates | ||||||||
| Parameters | Studies | IG | CG | P | OR | 95% CI | Heterogeneity P (I2) | Model |
| mRS 0 to 1 at 90 days | ||||||||
| Age ≤70 years | 1[16] | 131/246 | 102/244 | 0.010 | 1.59 | 1.11–2.27 | – | Random |
| Age >70 years | 2[17,18] | 61/173 | 49/168 | 0.230 | 1.32 | 0.84–2.09 | 0.96 (0) | Random |
| NIHSS ≤10 | 2[16,18] | 152/306 | 118/300 | 0.009 | 1.54 | 1.11–2.13 | 0.71 (0) | Random |
| NIHSS >10 | 1[17] | 40/113 | 33/112 | 0.340 | 1.31 | 0.75–2.30 | – | Random |
| Time window 4.5 to 9.0 h | 2[17,18] | 61/173 | 49/168 | 0.230 | 1.32 | 0.84–2.09 | 0.96 (0) | Random |
| Time window >9.0 h | 1[16] | 131/246 | 102/244 | 0.010 | 1.59 | 1.11–2.27 | – | Random |
| mRS 0 to 2 at 90 days | Random | |||||||
| Age ≤70 years | 2[14,16] | 186252 | 160/250 | 0.280 | 2.35 | 0.50–11.14 | 0.18 (44%) | Random |
| Age >70 years | 2[17,18] | 85/173 | 73/168 | 0.290 | 1.26 | 0.82–1.93 | 0.79 (0) | Random |
| NIHSS ≤10 | 2[16,18] | 211/314 | 184/300 | 0.040 | 1.43 | 1.02–2.02 | 0.52 (0) | Random |
| NIHSS >10 | 2[14,17] | 60/119 | 49/118 | 0.360 | 2.28 | 0.39–13.48 | 0.15 (51%) | Random |
| Time window 4.5 to 9.0 h | 2[17,18] | 85/173 | 73/168 | 0.290 | 1.26 | 0.82–1.93 | 0.79 (0) | Random |
| Time window >9.0 h | 2[14,16] | 57/260 | 58/255 | 0.540 | 2.01 | 0.21–19.03 | 0.09 (66%) | Random |
| sICH | Random | |||||||
| Age ≤70 years | 2[14,16] | 5/257 | 1/250 | 0.150 | 4.94 | 0.57–42.59 | – | Random |
| Age >70 years | 2[17,18] | 8/173 | 1/168 | 0.060 | 5.52 | 0.94–32.27 | 0.63 (0) | Random |
| NIHSS ≤10 | 2[16,18] | 6/311 | 1/300 | 0.120 | 4.17 | 0.70–24.97 | 0.78 (0) | Random |
| NIHSS >10 | 2[14,17] | 7/119 | 1/118 | 0.060 | 7.33 | 0.89–60.59 | – | Random |
| Time window 4.5 to 9.0 h | 2[17,18] | 8/173 | 1/168 | 0.060 | 5.52 | 0.94–32.27 | 0.63 (0) | Random |
| Time window >9.0 h | 2[14,16] | 5/257 | 1/250 | 0.150 | 4.94 | 0.57–42.59 | – | Random |
| Death | Random | |||||||
| Age ≤70 years | 2[14,16] | 10/257 | 3/250 | 0.070 | 3.33 | 0.91–12.26 | – | Random |
| Age >70 years | 2[17,18] | 20/173 | 14/168 | 0.320 | 1.44 | 0.70–2.95 | 0.74 (0) | Random |
| NIHSS ≤10 | 2[16,18] | 17/311 | 7/300 | 0.060 | 2.38 | 0.95–5.95 | 0.48 (0) | Random |
| NIHSS >10 | 2[14,17] | 13/119 | 10/118 | 0.520 | 1.33 | 0.56–3.16 | – | Random |
| Time window 4.5 to 9.0 h | 2[17,18] | 20/173 | 14/168 | 0.320 | 1.44 | 0.70–2.95 | 0.74 (0) | Random |
| Time window >9.0 h | 2[14,16] | 10/257 | 3/250 | 0.070 | 3.33 | 0.91–12.26 | – | Random |
IG: intravenous thrombolysis group; CG: Control group; mRS: modified Rankin Scale; sICH: symptomatic intracerebral; NIHSS: National Institute of Health Stroke Scale; h: hour; OR: odds ratio; CI: confidence interval.