Table 3.
Patient laboratory evaluation.
| Patient BP | Patient YM | Patient LB | ||
|---|---|---|---|---|
| Initial Laboratory Evaluation | Hemoglobin (g/dL) | 12.7 (5/20/2020) | 13.5 (3/1/2021) | 5.9 (6/3/2021) |
| Platelet count (X103) | 201 (5/20/2020) | 248 (3/1/2021) | 178 | |
| Serum creatinine (mg/dL) | 1.68 (5/20/2020) | 0.9 (3/1/2021) | 5.93 (6/3/2021) | |
| Urine protein/creatinine ratio (mg/g) | 786 (6/2/2020) | 1,900 (6/3/2021) | ||
| Urine albumin/creatinine ratio (mg/g) | 1,501 (2/20/2020) | 1,138 (3/1/2021) | 83% of urine protein | |
| Serum albumin (g/dL) | 4.0 (2/20/2020) | 4.2 (3/1/2021) | 3.4 (6/3/2021) | |
| LDH (IU/L) | 160 | 106 | 142 | |
| Haptoglobin (md/dL) | 130 | 118 | 236 | |
| Peripheral smear | No schistocytes | No schistocytes | No schistocytes | |
| ADAMTS13 activity (% normal) | >100% | 75% | ||
| C3/C4 (mg/dL) | 134/24 | 168/26 | 42/14 | |
| Factor H antibody (titer) | NA | NA | negative | |
| Soluble C5b-9 (ng/mL) | 191.7 | NA | NA | |
| ANA (titer) | negative | negative | negative | |
| DRVVT normalized ratio | normal | normal | normal | |
| Anticardiolipin Antibody (U/mL) | negative | negative | IgM 21.3 (non-significant) | |
| Anti-β2-glycoprotein I (U/mL) | negative | negative | NA | |
| Anti-Scl70 (U/mL) | negative | negative | negative | |
| SIEP | IgGκ | IgGκ | IgMκ | |
| UIEP | negative | IgGκ (faint) | Free κ | |
| Serum FLC ratio (mg/mg) | 1.93 | 1.27 | 8.5 | |
| Viral PCR (HIV, Hep B/C, CMV, EBV) | EBV 263 copies/ml (normal <200) | Negative or NA | Negative or NA | |
| Most recent Laboratory evaluation | Serum creatinine (mg/dL) | 1.9 (7/1/2021) | 1.37 (8/04/2021) | 3.21 (7/29/2021) |
| Urine protein/creatinine ratio (mg/g) | 59 (7/1/2021) | 111 (8/17/2021) | 2,800 (7/22/2021) | |
| Hemoglobin (g/dL) | 12.6 (7/1/2021) | 12.3 (8/04/2021) | 8.0 (7/29/2021) | |
| Platelet count (X103) | 158 (7/1/2021) | 229 (8/04/2021) | 153 (7/29/2021) | |
| Genetic analysis | C3, Factor H, Factor I, THB | negative | negative | negative |
ANA, antinuclear antibody; CMV, cytomegalovirus; DRVVT, dilute Russel viper venom time; EBV, Epstein-Barr virus; FLC, free light chain; LDH, lactate dehydrogenase; NA, not available; PCR, polymerase chain reaction; SIEP, serum immunofixation electrophoresis; THB, thrombomodulin; U, units; UIEP, urine immunofixation electrophoresis.
Bolded values are abnormal, all others are within normal limits.