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. 2021 Nov 10;8:768947. doi: 10.3389/fcvm.2021.768947

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Copyright © 2021 Li, Xu, Li, Li, Wang, Chen, Wang, Feng, Yin and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of MA on high mobility group box 1 (HMGB1)- toll-like receptor 4 (TLR4)- myeloid differentiation factor 88 (MyD88)-NF-κB pathway after H/R treatment. (A) Western blotting was performed to assess the expression of HMGB1, TLR4, MyD88, p65, P-p65, IκBα, and P-IκBα in H9c2 cell under H/R conditions. (B–F) The quantitative analyses of HMGB1, TLR4, MyD88, P-p65/p65, and P-IκBα/IκBα are shown in bar graphs. All the values are representative of at least three independent experiments and expressed as the mean ± SD. **P < 0.01 vs. control group; ^#P < 0.05 and ^##P < 0.01 vs. H/R group.