Figure 3.

PDGFD expression is associated with the activation of protumorigenic pathways and poor prognosis in BLCA. (A) Cancer hallmark signaling pathways associated with PDGFD expression in BLCA tumors and normal bladder tissue. Color-coded heatmaps represent the statistical significance of the functionally enriched pathways. Color toward red indicates the most significant pathways, while the yellow color represents less significant and gray color represents the non-significant events. Only selected significant terms were presented within the heatmaps. Kaplan–Meier survival curves constructed for (B) PDGFD or (C) PDGFRB expression in BLCA tumors. High tumor expression of PDGFD is associated with poor BLCA prognosis (x-axis, days; y-axis, progression-free survival).