Figure 4.

Tumor abundance of IL2NK, but not the SPANK, counteracts the protumorigenic effects of PDGFD on BLCA patient prognosis. Combined BLCA patient survival analysis stratified for tumor expression (median split) of PDGFD and each NK cell phenotype, ReNK, IL2NK, and SPANK, respectively. KM curves display the survival of BLCA patients plotted in all four combinations for each stratum, respectively (L/L, L/H, H/L, and H/H). Low PDGFD expression and high IL2NK abundance in BLCA tumors are associated with improved prognosis, whereas low expression of PDGFD and abundance of the SPANK phenotype in BLCA tumors are associated with a poor prognosis (x-axis, days; y-axis, progression-free survival).