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. 2021 Nov 10;12:724107. doi: 10.3389/fimmu.2021.724107

Figure 5.

Figure 5

Tumor expression of activating NK cell receptors is associated with the IL2NK phenotype and a more favorable BLCA prognosis. (A) KM plots displaying progression-free survival of BLCA patients stratified for tumor expression (median split) of KLRK1 (x-axis, days; y-axis, progression-free survival). (B) Combined BLCA patient survival analysis stratified for tumor expression (median split) for CD160 and TNFRSF14. KM curves display the survival of BLCA patients plotted for the highest strata of expression for CD160 and TNFRSF14 (H/H) compared with all other strata combinations for CD160 and TNFRSF14 combined. High tumor abundance of CD160 and TNFRSF14 is associated with improved BLCA prognosis (x-axis, days; y-axis, progression-free survival). (C) Heatmap displaying correlations between the expression of each NK cell receptor transcript (y-axis) and immune cell phenotype (x-axis), respectively (Tcm, central memory T cell; Tem, effector memory T cell; Treg, regulatory T cell).