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. 2021 Nov 10;12:737065. doi: 10.3389/fimmu.2021.737065

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Copyright © 2021 Tastan, Arioz, Tufekci, Tarakcioglu, Gonul, Genc and Genc

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DMF alleviated sickness behaviors in LPS-challenged mice. DMF administration to LPS-challenged mice prevented weight loss and improved clinical and behavioral scores. (A) A schematic representation of the study design (B) Clinical evaluation of mice (n=7/group) and (C) Changes in the weight of mice. Assessment of sickness behaviors was conducted with OFT (D), TST (E), and FST (F). Data are presented as mean ± S.E.M, n = 5. *p < 0,05, **p < 0.01 compared to control, ^#p < 0.05, ^##p < 0.01, ^###p < 0,001 compared to LPS-challenged mice, ^$p < 0,05, ^$$p < 0,01 compared to DMF-administered mice.