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Lung and circulating cytokine concentrations are exaggerated in hepSTAT3−/− mice during endotoxemia. WT and hepSTAT3−/− mice were treated for 18 h with i.p. LPS, and the indicated cytokines were quantified in (A) lungs and (B) plasma by Luminex multiplex bead array. Data are represented as means with SEM, and significance was determined using an unpaired t test; *p < 0.05. n = 7–11/group from two independent experiments. nd, not detectable.
