FIGURE 5.

Lungs are histologically unaffected by liver STAT3 deletion after endotoxemia with or without pneumonia. WT and hepSTAT3^−/− mice were given 18 h i.p. saline (n = 2–5 from two independent experiments), 18 h i.p. LPS (n = 6–7 from two independent experiments), or 18 h i.p. LPS followed by 24 h i.t. E. coli (n = 4–7 from three independent experiments). Nonperfused left lung lobes were collected, paraffin embedded, and stained with H&E. Representative images of all groups from at least two independent experiments illustrate comparable lung architecture under all three conditions between WT and hepSTAT3^−/− lungs.