FIGURE 7.

The composition of alveolar exudate is modified by hepatic acute-phase changes. WT and hepSTAT3^−/− mice were given 18 h i.p. LPS with or without an additional 24-h challenge with i.t. E. coli. BALF was subjected to MS. (A) Significant pneumonia-induced protein differences (FDR < 0.05) were determined for endotoxemic WT (white circle) and hepSTAT3^−/− (gray circle) mice, with shared and genotype-specific differences illustrated as a Venn diagram. (B) Canonical pathways (top five) unique to WT mice were determined using IPA (n = 4/group from two independent experiments).