. Author manuscript; available in PMC: 2021 Nov 30.

Published in final edited form as: J Immunol. 2021 Sep 1;207(7):1891–1902. doi: 10.4049/jimmunol.2100254

Table I.

Top 15 predicted upstream regulators of DEGs

Upstream Regulators	p Value of Overlap
TNF	9.76E–47
IL-1B	6.69E–31
IFNG	3.22E–25
TGFB1	8.05E–22
NFKBIA	1.79E–20
IL-4	2.78E–18
Ige	4.94E–18
NF-κB (complex)	3.37E–16
STAT3	4.65E–16
DUSP1	8.49E–16
Vegf	1.41E–15
CSF2	1.49E–15
IKBKG	2.31E–15
HIF1A	3.97E–15
IKBKB	6.25E–15

The 1898 DEGs (FDR < 0.05) between endotoxemic WT and hepSTAT3^−/− lungs were analyzed using IPA, and the predicted top 15 upstream regulators of hepSTAT3^−/− lungs (versus WT) after endotoxemia are listed.