Table 1.
Clinical and laboratory data at presentation.
| Patient N | Gender | Age | Ca blood (mg/dl) | P blood (mg/dl) | PTH (pg/ml) (N 14–53) | 1,25-D (pmol/l) (N 39–160) | Ca/Crea urine (mg/mg) | Clinical presentation | US |
|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 4 mo | 13.7 (N 9–11) |
4.9 (N 4–6.5) |
6.2 | 262 | 0.8 (N <0.8) | Repeated vomiting, weight loss | NC (grade2) |
| 2 | F | 10 mo | 11.4 (N 9–11) |
6.2 (N 4–6.5) |
8.4 | 400 | n/a | Asymptomatic | NC (grade 1) |
| 3 | M | 9 mo | 10.4 (N 9–11) |
5.9 (N 4–6.5) |
14.5 | 191 | 1 (N <0.6) | US done due to preauricular skin tag | NC (grade 2)–>NL (2y) |
| 4 | M | 11 y | 10.4 (N 8.8–10.8) |
4.8 (N 3.3–5.4) |
9.6 | 533 | 0.4 (N <0.2) | Abdominal pain | NL |
| 5 | M | 1 mo | 11.5 (N 9–11) |
5.3 (N 4–6.5) |
7.7 | 442 | 2 (N <0.8) | Asymptomatic | N |
| 6 | M | 3 y | 11.3 (N 8.8–10.8) |
6.5 (N 3.2–5.8) |
3.5 | 264 | 0.9 (N <0.4) | Renal colic | NL |
| 7 | M | 7 y | 9.8 (N 8.8–10.8) |
5.6 (N 3.2–5.8) |
5.5 | 202 | 0.4 (N <0.2) | Polyuria, nocturnal enuresis | NL |
| 8 | F | 1 mo | 11.1 (N 9–11) |
7.8 (N 4–6.5) |
7.5 | 364 | 1 (N <0.8) | Asymptomatic | N |
| 9 | F | 7 mo | 11 (N 9–11) |
5.5 (N 4–6.5) |
5.5 | 181 | 0.5 (N <0.6) | Urinary tract infection | NC (grade 3) |
| 10 | F | 2 y | 10.7 (N 8.8–10.8) |
4.9 (N 4–6.5) |
2 | 190 | 0.44 (N <0.4) | Abdominal pain | NC (grade 3) |
| Summary Data | 6 males | Median 9.5 mo (range 1 mo−11 y) |
Mean ± SD 11.1 ± 1 |
Mean ± SD 5.74 ± 0.87 |
Mean ± SD 7 ± 3.5 |
Mean ± SD 307 ± 130 |
Hypercalciuria-8, borderline calciuria-1 | NC-5 NL-3 N-2 |
F, female; M, male; Y, years; Mo, months; n/a, not available; NC, nephrocalcinosis; NL, nephrolithiasis; N, normal; Ca, calcium; PTH, parathyroid hormone; US, ultrasound.
Normal blood calcium and phosphor levels for age are noted in parenthesis (Tietz clinical guide to laboratory tests, 4th edition).
Normal urinary calcium/creatinine ratios for age are noted in parenthesis (13, 14).