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. 2021 Nov 10;12:771552. doi: 10.3389/fendo.2021.771552

Table 3.

The role of miRNA ln and lncRNA in DR and their mechanisms through müller cell and targets.

ncRNA Name Dysregulation Possible signaling pathways Pathogenic functions in Müller cells Reference
lncRNA MIAT upregulated TXNIP, miR-29b/Sp1 promote inflammation and apoptosis (112)
OGRU upregulated miR-320/USP14 promote oxidative stress and inflammation (113)
NEAT1 downregulated miR-497/BDNF inhibit apoptosis (114)
miRNA miR-486-3p downregulated TLR4/NF-κB inhibit oxidative stress, inflammation, apoptosis and angiogenesis (105)
miR-320a downregulated AQP4 inhibit hypoxia injury (106)
miR-29a/b downregulated FOXO4 decreased the glutamate level (107)
miR-365 upregulated Timp3 promote oxidative stress (108)