TABLE 1.
Behavioral effects of interventions to P2X7R expression and functions.
| Genetic interventions | Species | Results | References |
|---|---|---|---|
| P2RX7−/− | C57BL/6 mice | Decreased immobility time in TST and FST.Reduced anhedonia in SPT after stimulation with a bacterial endotoxin, lipopolysaccharide | Basso et al., (2009), |
| Csolle et al. (2013a), | |||
| Csolle et al. (2013b) | |||
| hP2X7R/hP2RX7-Gln460Arg homozygotes and heterozygotes | C57BL/6 mice | Basal levels of depressive-like behavior were unaltered. CSDS induced increased social avoidance, decreased time spent in open arms in EPM in all genotypes studied. | Metzger et al. (2017) |
| hP2RX7-WT-hP2RX7-Gln460Arg heterozygotes | C57BL/6 mice | Decreased slow wave activity&NREM sleep duration and increased number of REM sleep bouts | Metzger et al. (2017) |
| IP3R2 −/− | C57BL/6 mice | Selective inhibition of astrocytic ATP release lead to increased behavioral despair and anhedonia | Cao et al. (2013) |
| P2X7R AGONISTS | |||
| ATP/ATP-γ-S (icv) | C57BL/6J mice | Reversed social avoidance caused by CSDS and anhedonia caused by CUMS | Cao et al. (2013) |
| ATP/ATP-γ-S (intra mPFC) | Reversed the increase in immobility time in FST | ||
| ATP/BzATP (intrahippocampal, 3 weeks) | SD rats | Increased immobility time in FST | Yue et al. (2017) |
| P2X7R ANTAGONISTS | |||
| BBG/A438079 (3 weeks, intrahippocampal, with CUS) | SD rats | Reversed increased immobility caused by CUS | Yue et al. (2017) |
| A-804598 (4 weeks, ip with CUS) | SD rats | Reversed CUS-induced deficits in SPT, NSFT and EPM | Iwata et al. (2016) |
| Brilliant Blue G (1 week, ip) | C57BL/6 mice | Decreased immobility time in TST | Csölle et al. (2013a) |
| PPADS into mPFC | C57BL/6 mice | Blocked the antidepressant-like effect of ATP on immobility time in FST | Cao et al. (2013) |
ATP, adenosine triphosphate; CSDS, chronic social defeat stress; CUMS, chronic unpredictable mild stress; CUS, chronic unpredictable stress; EPM, elevated plus maze; FST, forced swim test; icv, intracerebroventricular; IP3R2, inositol 1,4,5- trisphosphate receptor type 2; ip, intraperitoneal; mPFC, medial prefrontal cortex; NSFT, novelty suppressed feeding test; SD, Sprague-Dawley; SPT, sucrose preference test; TST, tail suspension test.