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. 2021 Nov 10;12:674074. doi: 10.3389/fimmu.2021.674074

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Copyright © 2021 Zhang, Shao, Dang, Chen, Zhou, Luo, Yuan and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The S protein of COVID-19 infects the host by combining with ACE2. After the virus infects the host, the expression of ACE2 protein is downregulated. ACE2 converts Ang II, the main biologically active molecule of RAS, to Ang 1-7; Ang (1Mel7) has anti-inflammatory and anti-remodeling effects after binding to the Mas receptor and coupling with Gq protein. Therefore, after the virus infects the host, it is likely to cause the intestinal anti-inflammatory ability to decrease.