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. 2021 Nov 10;12:748881. doi: 10.3389/fimmu.2021.748881

Figure 3.

Figure 3

SARS-CoV-2-specific T cells from individuals with OTD produce more IFNγ than patients with severe COVID-19. (A, B) Amount of IFNγ (pg/mL) in the supernatants of AIM assay after PBMC stimulation with CD4-specific MP_R and MP_S peptide pools. Data are shown in comparison with the vehicle control (DMSO), per donor. (C, D) DMSO-subtracted IFNγ concentrations (pg/mL) after MP_R and MP_S stimulation in SARS-CoV-2 negative subjects with olfactory-taste disorder (nOTD), SARS-CoV-2 positive subjects with olfactory-taste disorder (pOTD) and severe COVID-19 patients. (E, F) IFNγ levels in the AIM supernatants after stimulation with CD8-specific MP_A or MP_B peptide pools. Data are shown in comparison with the vehicle control (DMSO), per donor. (G, H) Comparison of the background (DMSO)-subtracted IFNγ levels across the three cohorts of patients after MP_A and MP_ B stimulation. The non-parametric Wilcoxon matched-pairs signed-rank test was used to compare data within the same group. Statistical comparison between three groups of subjects was assessed by the non-parametric Kruskal-Wallis test followed by Dunn’s multiple comparisons. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.