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. 2021 Nov 10;12:741093. doi: 10.3389/fmicb.2021.741093

TABLE 1.

Summary of all carbapenem-resistant Klebsiella pneumoniae strains revealed by WGS data and virulence assay in this study.

Strains STs/capsular types Antimicrobial resistance genes Virulence genes String test Galleria mellonella larvae infection (survival rate at 72 h) Virulence scoreb
C13 ST11/KL64 qnrS1, aadA2, rmtB, blaCTX–M–65, blaKPC–2, blaSHV–12, blaTEM–1B, catA2, dfrA14, fosA, sul2, tet(A) Yersiniabactin, aerobactin, rmpA, rmpA2 Negative 20% 4
C32 ST11/KL64 qnrS1, rmtB, blaCTX–M–65, blaKPC–2, blaSHV–12, blaTEM–1B, catA2, fosA, sul2, tet(A) Yersiniabactin, aerobactin, rmpA, rmpA2 Negative —a 4
C34 ST11/KL64 qnrS1, aadA2, rmtB, blaCTX–M–65, blaKPC–2, blaSHV–12, blaTEM–1B, dfrA14, fosA, sul2, tet(A) Yersiniabactin, aerobactin, rmpA, rmpA2 Negative — 4
C36 ST11/KL64 qnrS1, aadA2, rmtB, blaCTX–M–65, blaKPC–2, blaSHV–12, blaTEM–1B, dfrA14, fosA, sul2, tet(A) Yersiniabactin, aerobactin, rmpA, rmpA2 Negative — 4
C24 ST11/KL64 qnrS1, aadA2, rmtB, blaCTX–M–65, blaKPC–2, blaSHV–12, blaTEM–1B, catA2, dfrA14, fosA, sul2, tet(A) Yersiniabactin, aerobactin, rmpA, rmpA2 Negative — 4
C33 ST11/KL64 qnrS1, aadA2, blaCTX–M–65, blaKPC–2, blaSHV–11, fosA, sul2, tet(A) Yersiniabactin, aerobactin, rmpA, rmpA2 Negative — 4
C26 ST11/KL64 qnrS1, rmtB, blaCTX–M–65, blaKPC–2, blaSHV–12, blaTEM–1B, catA2, dfrA14, fosA, tet(A) Yersiniabactin, aerobactin, rmpA2 Positive 0% 4
C5 ST11/KL64 qnrB4, aac(3)-IId, aadA2, armA, blaDHA–1, blaKPC–2, blaSHV–11, blaTEM–1B, catA2, fosA, mph(A), mph(E), msr(E), Yersiniabactin, aerobactin, rmpA2 Negative — 4
C19 ST11/KL64 aadA2, rmtB, blaCTX–M–65, blaKPC–2, blaSHV–12, blaTEM–1B, fosA Yersiniabactin, aerobactin, Salmonchelin, rmpA, rmpA2 Negative 0% 4
C14 ST11/KL64 aadA2, rmtB, blaCTX–M–65, blaKPC–2, blaSHV–12, blaTEM–1B, fosA Yersiniabactin, aerobactin, Salmonchelin, rmpA, rmpA2 Negative 0% 4
C23 ST11/KL64 aadA2, rmtB, blaCTX–M–65, blaKPC–2, blaSHV–12, blaTEM–1B, fosA, dfrA12, mph(A) Yersiniabactin, aerobactin, rmpA2 Negative — 4
C31 ST11/KL110 aadA2, rmtB, blaCTX–M–65, blaKPC–2, blaSHV–12, blaTEM–1B, fosA, dfrA12, mph(A) Yersiniabactin, aerobactin, Salmonchelin, rmpA, rmpA2 Negative 0% 4
C16 ST11/KL10 ARR-3, oqxA, oqxB, aac(3)-IId, aac(6′)Ib, aadA16, aadA2, aph(3′)-Ia, strA, strB, blaCTX–M–15, blaKPC–2, blaSHV–11, dfrA27, fosA, mph(A), tet(A) Yersiniabactin Negative — 1
C10 ST11/KL25 qnrS1, oqxA, oqxB, aac(3)-IId, aadA2, rmtB, strA, strB, blaCTX–M–65, blaKPC–2, blaSHV–11, blaTEM–1B, catA2, dfrA14, fosA, sul2, tet(A), tet(D) Yersiniabactin Negative — 1
C8 ST11/KL47 oqxA, oqxB, aadA2, rmtB, blaCTX–M–65, blaKPC–2, blaSHV–11, blaTEM–1B, catA2, fosA Yersiniabactin Negative — 1
C25 ST11/KL47 qnrB6, qnrS1, blaCTX–M–3, blaKPC–2, blaSHV–11, blaTEM–1B, dfrA14, fosA Yersiniabactin Negative — 1
C18 ST11/KL47 oqxA, oqxB, rmtB, blaCTX–M–65, blaKPC–2, blaSHV–12, blaTEM–1B, catA2, fosA Yersiniabactin, aerobactin, rmpA2 Negative — 4
C30 ST11/KL47 oqxA, oqxB, aadA2, rmtB, blaCTX–M–65, blaKPC–2, blaSHV–11, blaTEM–1B, catA2, fosA, mph(E) Yersiniabactin, aerobactin, rmpA2 Negative — 4
C27 ST11/KL47 oqxA, oqxB, aac(6′)Ib, aadA2, aph(3′)-Ia, blaCTX–M–15, blaCTX–M–65, blaKPC–2, blaOXA–1, blaSHV–11, blaTEM–1B, catA2, fosA, tet(A) Yersiniabactin, aerobactin, rmpA2 Negative — 4
C38 ST11/KL47 oqxA, oqxB, aac(6′)Ib, rmtB, aph(3′)-Ia, blaCTX–M–15, blaCTX–M–65, blaKPC–2, blaOXA–1, blaSHV–11, blaTEM–1B, catA2, fosA, tet(A) Yersiniabactin, aerobactin, rmpA2 Negative 0% 4
C7 ST11/KL47 oqxA, oqxB, aac(6′)Ib, aadA2, rmtB, aph(3′)-Ia, blaCTX–M–15, blaCTX–M–65, blaKPC–2, blaOXA–1, blaSHV–11, blaTEM–1B, fosA, tet(A) Yersiniabactin, aerobactin, rmpA2 Negative — 4
C9 ST11/KL47 oqxA, oqxB, aac(6′)Ib, rmtB, aph(3′)-Ia, blaCTX–M–65, blaKPC–2, blaOXA–1, blaSHV–11, blaTEM–1B, fosA, tet(A) Yersiniabactin, aerobactin, rmpA2 Negative — 4
C35 ST11/KL15 oqxA, oqxB, aac(3)-IId, blaKPC–2, blaSHV–11, fosA, tet(D) Yersiniabactin Negative — 1
C4 ST11/KL62 ARR-3, oqxA, oqxB, aac(3)-IId, aadA16, strA, strB, blaCTX–M–14, blaKPC–2, blaSHV–11, blaTEM–1B, dfrA27, fosA, mph(A), sul1, sul2, tet(D) Yersiniabactin Negative — 1
C37 ST37/KL15 ARR-3, qnrA7, oqxA, oqxB, aac(3)-IId, blaNDM–1, blaSFO–1-like, blaSHV–11, blaTEM–1B, blaVEB–3, dfrA27, fosA, mph(A), sul1 Yersiniabactin Negative — 1
C39 ST37/KL15 ARR-3, qnrA7, oqxA, oqxB, aac(3)-IId, blaNDM–1, blaSFO–1-like, blaSHV–11, blaTEM–1B, blaVEB–3, dfrA27, fosA, mph(A), sul1 Yersiniabactin Negative — 1
C11 ST1383/KL110 oqxA, oqxB blaNDM–1, blaSHV–11, fosA, blaSHV–12 None Negative — 0
C12 ST1383/KL110 oqxA, oqxB blaNDM–1, blaSHV–11, fosA, blaSHV–12 None Negative — 0
C20 ST304/KL2 qnrS1, oqxA, oqxB, aac(3)-IId, aadA2, blaCTX–M–14, blaNDM–1, blaSHV–11, fosA Yersiniabactin Negative — 1
C6 ST15/KL24 qnrB4, oqxA, oqxB, aac(6′)-IIa, aadA2, armA, blaKPC–2, blaLEN15, dfrA14, fosA, mph(E), msr(E), sul1, sul2 Yersiniabactin, aerobactin, rmpA2 Positive 0% 4
C1 ST15/KL19 oqxA, oqxB, aac(3)-IId, aac(6′)Ib, aadA2, aph(3′)-Ia, strA, strB, blaCTX–M–15, blaDHA–1, blaKPC–2, blaOXA–1, blaSHV–28, blaTEM–1B, dfrA12, fosA, mph(A), sul1, sul2 None Negative — 0
C29 ST15/KL19 qnrB4, oqxA, oqxB, aac(3)-IId, aac(6′)Ib, aadA2, aph(3′)-Ia, armA, blaCTX–M–15, blaKPC–2, blaOXA–1, blaSHV–11, blaTEM–1B, catA2, fosA, mph(A), mph(E), msr(E), sul1 Yersiniabactin, aerobactin, rmpA2 Negative 0% 4
C21 ST2237/KL19 qnrB4, oqxA, oqxB, aph(3′)-Ia, armA, blaDHA–1, blaKPC–2, blaOXA–1, blaSHV–11, fosA, mph(E), msr(E), sul1 Yersiniabactin, aerobactin, rmpA2 Negative — 4
C17 ST2237/KL19 qnrB4, oqxA, oqxB, aac(3)-IId, aadA2, aph(3′)-Ia, armA, blaDHA–1, blaKPC–2, blaSHV–11, dfrA12, fosA, mph(A), mph(E), msr(E), sul1 Yersiniabactin, aerobactin, rmpA2 Negative — 4
C2 ST2237/KL19 qnrB4, oqxA, oqxB, aac(3)-IId, armA, blaDHA–1, blaKPC–2, blaSHV–11, fosA, mph(E), msr(E), sul1 Yersiniabactin, aerobactin, rmpA2 Negative — 4

aThe strain was not selected for Galleria mellonella larvae infection assay.

bVirulence score is determined by Kleborate software; virulence increases with the score.