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Cotton rats were infected intranasally with CI-1, CI-1 HN H552Q, CI-1 HN/F SC9779, and CI-1 HN/F SC9779 H552Q-T193A, and the left lungs were collected after 3 and 5 days. A 1-way ANOVA was performed to determine significance; P values are specified as follows: *P ≤ 0.05, **P ≤ 0.01, and ***P ≤ 0.001. TCID50, 50% tissue culture infectious dose.
