Figure 7. Effect of Scn2a ASO ED₅₀ administration in P1 +/+ mice.

(A) Body weight measured at P21. (B) Grip force. (C) Number of foot faults in grid walk test. #P < 0.05 (t = 2.207, df = 17), unpaired 2-tailed t test. (D) Ambulatory time measured in locomotor chamber. (E) Time spent in the different compartments of 3-chamber social interaction test. (F) Percentage duration spent in different arms of the elevated plus maze. **P < 0.01 (F (5, 54) = 8.512), 2-way ANOVA with Sidak’s multiple comparison, n = 8 to 20 per genotype. Data are represented as mean ± SEM.